Short Title:
Bone strength recovery
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
- Addressed the observed "discordant recovery dynamic" reported for astronaut data (Lang et al., JBMR 21:1224, 2006) by characterizing bone mass, bone mineral density (BMD), and bone strength relationships after HU and during various periods of recovery.
- Examined multiple mission scenarios using HU, recovery for a period, and then a second HU exposure.
- Followed the two-exposure protocol but with exercise (both aerobic and resistive) added during the recovery period.
Integration/Unique Aspects: Proximal tibia micro-CT: results were generated from a collaboration with another HRP-funded investigator Dr. Stefan Judex at Stony Brook University. The data provided results with much higher resolution and greater insight into the details of the effects of hindlimb unloading and recovery upon the proximal tibia metaphysis, including both trabecular bone and the cortical shell.
Category:
Technology or Tool
Subcategory:
Informatics
Description:
Rodent study with hind-limb unloading, designed to model the effects of multiple spaceflilght missions which informs subsequent human studies.
Task to Gap contribution: Multiple spaceflight missions may be a risk factor for declines in bone strength and increased fracture risk. This task used an animal model to evaluate a recovery pattern in bone structure and strength with repeat exposures to rodent unloading and during intervening periods.
Internal Customers:
Human Health Countermeasures
External Customers:
None