Short Title:
Intervertebral Disc Damage (IVD post-spaceflight)
Responsible HRP Element:
Human Health Countermeasures
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Collaborating Org(s):
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| Research Operations and Integration (ROI) |
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Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
- Use state-of-the-art imaging technologies to quantify morphology, biochemistry, metabolism, and kinematics for the vertebral body units of the lumbar spine (including the intervertebral discs) of crew members before and after prolonged space flight.
- Correlate these data with low back pain that spontaneously arises in space to establish pain and disc damage mechanisms.
- Provide a comprehensive database of microgravity-induced intervertebral disc and vertebral changes (type and magnitude) and a prioritization of these changes as to their deleterious effects and risks for crew member injury based on clinical findings.
Integration/Unique Aspects: Data share with Spinal Ultrasound (Dulchavsky PI) study where study participants overlap.
Category:
Technology or Tool
Subcategory:
Informatics
Description:
Quantification of morphology, biochemistry, metabolism and kinematics for lumbar discs of crew members before and after prolonged space flight.
The data will be correlated with low back pain that spontaneously arises in space so as to establish pain and disc damage mechanisms that will serve as a basis for future countermeasure development.
Internal Customers:
None
External Customers:
None
Category:
Countermeasure
Subcategory:
Prototype Hardware or Software
Description:
This Task contributes to Gap closure by conducting seminal measurements of spaceflight (pre-flight and postflight measures) correlating to the manifestation of back pain.
Internal Customers:
None
External Customers:
None