Task Clearance of Particles Depositing in the Human Lung in Low-Gravity (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Human Lung Low g
Responsible HRP Element: Space Human Factors and Habitability
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
The specific aim of this task is to test the hypothesis that clearance rates from the lung of particles deposited in low-gravity will be substantially reduced compared to that in 1G, resulting in increased residence times of these particles in the periphery of the lung, enhancing their potential to cause lung damage.

Finding obtained from measures made during multiple periods of microgravity (μG) aboard the NASA Microgravity Research Aircraft during parabolic flight and in gravity (1G) have shown that gravity has a significant effect on deposition patterns of 99mTc-labeled sulfur colloid, 5.1 μm particles with most of deposition occurring in the alveolar region in 1G, but in the large airways in μG.