Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: SR Risk Assessment-Cucinotta
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Terminated - A formerly active task that was stopped before its completion date due to deselection, descoping, reorganization etc.
Procurement Mechanism(s):
Directed
Aims:
  • Specific Aim A: To facilitate the integration of space radiobiology research results into improved models of BR radiation risk projections.
  • Specific Aim B: To complete the cancer risk uncertainty analysis factors to be used for near-term mission planning (trade studies), and to update these as new radiobiological data sets become available.
  • Specific Aim C: To develop descriptive and predictive models of modifications to biochemical pathways known likely to be causative of cancer risk.
  • Specific Aim D: To integrate or develop new data and models of DNA damage, transmissible chromosomal aberration including translocation, insertions, terminal deletion including telomere loss, and other aberrations related to chromosomal instability or cancer initiation, incorporating applications to the simulations in Specific Aim C.
  • Specific Aim E: To perform a comprehensive assessment of available acute radiation risk projection models, and to develop simulation software of acute risk for mission design assessments.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCancer 11: What are the most effective shielding approaches to mitigate cancer risks?
GapCancer 12: What quantitative models, numerical methods, and experimental data are needed to accurately describe the primary space radiation environment and transport through spacecraft materials and tissue to evaluate dose composition in critical organs for mission relevant radiation environments (ISS, Free-space, Lunar, or Mars)?
GapCancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.
GapCancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
GapCancer-102: Determine the role of radiation quality on carcinogenesis and shared biology with other degenerative diseases.
You are here!TaskSpace Radiation Risk Assessment Project-Cucinotta

RiskRisk of Acute Radiation Syndromes Due to Solar Particle Events (SPEs)
You are here!TaskSpace Radiation Risk Assessment Project-Cucinotta

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
You are here!TaskSpace Radiation Risk Assessment Project-Cucinotta

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
GapCancer-102: Determine the role of radiation quality on carcinogenesis and shared biology with other degenerative diseases.
GapCancer 11: What are the most effective shielding approaches to mitigate cancer risks?
GapCancer 12: What quantitative models, numerical methods, and experimental data are needed to accurately describe the primary space radiation environment and transport through spacecraft materials and tissue to evaluate dose composition in critical organs for mission relevant radiation environments (ISS, Free-space, Lunar, or Mars)?
GapCancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
GapCancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.
You are here!TaskSpace Radiation Risk Assessment Project-Cucinotta

RiskRisk of Radiation Carcinogenesis
GapCancer-102: Determine the role of radiation quality on carcinogenesis and shared biology with other degenerative diseases.
GapCancer-201: Determine the role of dose-rate in space radiation-induced carcinogenesis.
GapCancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
GapCancer-401: Identify biomarkers for estimating individual susceptibility, risk assessment, and health monitoring.
GapCancer 11: What are the most effective shielding approaches to mitigate cancer risks?
GapCancer 12: What quantitative models, numerical methods, and experimental data are needed to accurately describe the primary space radiation environment and transport through spacecraft materials and tissue to evaluate dose composition in critical organs for mission relevant radiation environments (ISS, Free-space, Lunar, or Mars)?
You are here!TaskSpace Radiation Risk Assessment Project-Cucinotta

RiskRisk of Spaceflight Induced Cardiovascular Disease
You are here!TaskSpace Radiation Risk Assessment Project-Cucinotta