Task Effects of Estrogen on Cataract Induction After Exposure to High LET Radiation (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: Estrocataract
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
The first Specific Aim shall be to define the dose-time interactions of high LET radiation (vs. low LET radiation) and estradiol to better understand the mechanism of estrogen action. The RBE for cataractogenesis in estrogen-treated animals exposed to1 GeV iron beams shall be determined using 60-Co gamma rays as a standard. The second specific aim shall be to determine the mechanism of estrogen-modulation of radiation-induced cataracts. Animal and cell culture studies will be performed to determine the effects of estrogen on gene expression, cell proliferation, apoptosis, and the induction and repair of radiation-induced DSBs. Slit-lamp biomicroscopy will be used to measure lens opacification in exposed animals.
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