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Task Effects of Estrogen on Cataract Induction After Exposure to High LET Radiation (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Task Book: Entry
Principal Investigator: Dynlacht, Joseph
Short Title: Estrocataract
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
The first Specific Aim shall be to define the dose-time interactions of high LET radiation (vs. low LET radiation) and estradiol to better understand the mechanism of estrogen action. The RBE for cataractogenesis in estrogen-treated animals exposed to1 GeV iron beams shall be determined using 60-Co gamma rays as a standard. The second specific aim shall be to determine the mechanism of estrogen-modulation of radiation-induced cataracts. Animal and cell culture studies will be performed to determine the effects of estrogen on gene expression, cell proliferation, apoptosis, and the induction and repair of radiation-induced DSBs. Slit-lamp biomicroscopy will be used to measure lens opacification in exposed animals.
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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskEffects of Estrogen on Cataract Induction After Exposure to High LET Radiation
RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskEffects of Estrogen on Cataract Induction After Exposure to High LET Radiation
RiskRisk of Radiation Carcinogenesis
You are here!TaskEffects of Estrogen on Cataract Induction After Exposure to High LET Radiation
RiskRisk of Spaceflight Induced Cardiovascular Disease
You are here!TaskEffects of Estrogen on Cataract Induction After Exposure to High LET Radiation