Task Human endothelial cells in 2-D and 3-D systems; non-cancer effects and space-related radiations (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: 2,3-D Skin
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
We propose to irradiate 2D [cell monolayers] and 3D [capillary-like cell structures] with Fe ions at 1GeV with doses where a bystander effect may apply [< 0.1 Gy] to doses where multiple traversals are expected [up to 1Gy]. We will compare responses to low LET X-rays and to alpha particles at the same LET as the Fe ions, where delta rays are less likely to be influential. Chromosomal changes using G2-PCC`s and state of the art m-FISH, micronuclei, apoptosis and cell-cell, cell-matrix interacting proteins will be quantified.
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