Task Mechanisms, early events, and dose dependence of radiation-induced atherosclerosis (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: SR Atherosclerosis
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

Aim 1: Determine whether atherogenic effects of radiation are limited to local effects on vascular endothelium, or if other systems contribute to disease progression and/or modify dose dependence.

Aim 2: Determine the molecular mechanism of acute activation of leukocyte-endothelial cell adhesion in response to radiation.

Aim 3: Determine how fractionation of doses affects dose-dependence of progression rates, latency periods, and surrogate endpoints.

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