Task Dose-rate effects of protons on the induction of genomic instability in vivo (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Short Title: Genomic Invivo
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
In this project, we determine the type, the frequency, and the distribution of initial and subsequent chromosome aberrations, and the expression of genomic instability (assessed as late occurring chromosomal damage) induced in vivo in BM cells after exposure of mice to 100 MeV protons at the dose and dose rates encountered in space. Chromosomal damage is selected as an endpoint for the detection of proton-induced damage because of its strong correlation with the induction of cancers.
Further, we also studied the effects of protons on the formation/reduction of phosphorylated histone 2AX (gamma H2AX), a biomarker for DNA double strand breaks, and on the cell cycle. Our results will deliver information that is of high priority for NASA in developing a better policy on safety limit and risk assessment associated with prolonged space flights.
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