Task The mechanism of excess relative risk on carcinogenesis induced by high-LET radiation (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Relative LET Risk
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Determine whether the major reason for high LET IR inducing excess deaths in cells and in mice is because of inefficient Ku-dependent NHEJ repair.
  2. Determine whether the major reason for high LET IR inducing excess relative risk (ERR) on carcinogenesis in mice is because of inefficient Ku-dependent NHEJ repair.
  3. Determine whether the major reason for high LET IR inducing excess relative risk (ERR) on genomic instability is because of inefficient Ku-dependent NHEJ repair.
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