Task Radiation and Gliomagenesis: A Sensitive Model System to Evaluate the Tumorigenic Potential of HZE Particles (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: HZE Gliomagenesis
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

Aim 1: Evaluation of DNA damage responses to charged particles in neural stem cells (NSCs) and astrocytes in vitro and in vivo.

Aim 2: Evaluation of the tumorigenic potential of charged particles relative to gamma rays in vitro and in vivo.

Aim 3: Identification of the genetic and gene expression changes underlying particle-induced tumorigenesis.

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