Task The Relation Between Mutagenesis and Genomic Instability After Particle Exposure In Vivo (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Genomic & Mutagenesis
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
The proposed work has three interrelated goals. The first is to document the induction of mutational processes leading to LOH in two tissues, lung and spleen. The mutagenic effects of three charged particles will be tested: 1 GeV/amu Fe ions, 1 GeV/amu Ti ions, and 1 GeV protons to address the impact of ionization density on mutagenesis. The second goal is to demonstrate that LOH occurs on multiple chromosomes in the induced mutant cells, which would suggest the development of genomic instability. The third goal is to demonstrate directly with novel color markers that genomic instability characterized by high levels of LOH develops in the progeny of cells exposed in vivo.
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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskThe Relation Between Mutagenesis and Genomic Instability After Particle Exposure In Vivo

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskThe Relation Between Mutagenesis and Genomic Instability After Particle Exposure In Vivo

RiskRisk of Radiation Carcinogenesis
You are here!TaskThe Relation Between Mutagenesis and Genomic Instability After Particle Exposure In Vivo