Task Radiation quality and the relationship between induced telomere dysfunction and mutagenesis (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Short Title: Telomere dysfunction
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
This research project will explore the effects of radiation quality on the dose-response relationship for telomere aberrations and gene mutations in human cells. It will relate these two potential cancer development processes by determining whether telomere-double strand break fusions are a significant contributor to the overall mutagenic response of a cell to ionizing radiation. Finally, it will explore various aspects of radiation-induced bystander effects, where cells not directly traversed by ionizing radiation nevertheless exhibit genetic damage.
Resources (None Listed)