Task Radiation quality and the relationship between induced telomere dysfunction and mutagenesis (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Telomere dysfunction
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
This research project will explore the effects of radiation quality on the dose-response relationship for telomere aberrations and gene mutations in human cells. It will relate these two potential cancer development processes by determining whether telomere-double strand break fusions are a significant contributor to the overall mutagenic response of a cell to ionizing radiation. Finally, it will explore various aspects of radiation-induced bystander effects, where cells not directly traversed by ionizing radiation nevertheless exhibit genetic damage.
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