Task Epigenetic effects of radiation on epithelial cell self-renewal (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Epithelial Renewal
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
Using a three-dimensional cell culture system that supports tissue-like behavior of human breast cells, we will: 1) determine the effects of ionization density and dose on the frequency of self-renewal versus differentiation, 2) identify biochemical pathways that show persistent changes as functions of ionization density and dose, and 3) use genetic manipulations to test the mechanistic involvement of discrete pathway components in persistent radiation quality effects.
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