Task Mitigating High Z Radiation Induced Genomic Instability by Non-Protein Thiols (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: High Z Genome
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
In this application we will investigate the radioprotective effect of three non-protein thiol drugs already approved for clinical use. This will be achieved by investigating three specific aims: Specific aim 1 will test the hypothesis that non-protein thiols can reduce the frequency of genomic instability induced by High Z particles in human cells. These human cells have been transfected with a sensitive and reliable reporter system to analyze delayed recombination/deletion events associated with radiation exposure in the progeny of surviving cells. Specific aim 2 will test the hypothesis that some of the delayed effects of high Z radiation result from nontargeted bystander effects resulting from soluble factors secreted by irradiated cells. Specific aim 3 will investigate the molecular mechanism(s) by which the non-protein thiols exert their protective effect.
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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskMitigating High Z Radiation Induced Genomic Instability by Non-Protein Thiols

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskMitigating High Z Radiation Induced Genomic Instability by Non-Protein Thiols

RiskRisk of Radiation Carcinogenesis
You are here!TaskMitigating High Z Radiation Induced Genomic Instability by Non-Protein Thiols