Task NSCOR: Solid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Solid Tumor Risk
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
We will improve solid tumor risk estimation for astronauts. Improvements will be based in large part on analyzing data resulting from our high-energy iron ion and proton in vivo irradiations. Our mathematical risk modeling will use standard computational approaches which minimize theoretical assumptions and also use minimally-parameterized, biologically-based carcinogenesis models capable of interrelating epidemiological data, animal experiments, and in vitro radiobiology. In our experiments and our computational analyses, special emphasis will be placed on tumor promotion and progression, as influenced by intercellular signaling among various cell populations within the tumor (e.g. tumor cells, endothelial cells and stroma).
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskNSCOR: Solid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskNSCOR: Solid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects

RiskRisk of Radiation Carcinogenesis
You are here!TaskNSCOR: Solid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects