Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: HZE Cancer Risk
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
Project 1 will test use novel transgenic and humanized mouse mammary models to evaluate the relative contribution of radiation targeted and NTE to carcinogenesis as a function of radiation quality and of age a radiation chimera model. We will monitor inflammation as a key process affected by radiation NTE and conduct a systems biology analysis of mammary gland. Project 2 will employ new systems genetic analysis of cancer susceptibility in radiation sensitive organs to define critical regulatory networks that impact the relative carcinogenic effectiveness of high LET radiation. Project 3 will use Monte Carlo simulations of targeted radiation effects and agent based modeling of cell interactions to model the relative contributions of targeted and NTE to carcinogenesis. This NSCOR will provide important data on radiation quality dependence of targeted and non-targeted radiation effects and the genetic determinants of cancer susceptibility, which together will used to reduce uncertainties in NASA radiation risk assessment.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskNSCOR: The contribution of non-targeted effects in HZE cancer risk

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskNSCOR: The contribution of non-targeted effects in HZE cancer risk

RiskRisk of Radiation Carcinogenesis
You are here!TaskNSCOR: The contribution of non-targeted effects in HZE cancer risk