Task NSCOR: NASA Specialized Center of Research on Radiation Carcinogenesis (Completed)
Last Published:  04/20/22 11:43:24 AM (Central)
Short Title: NSCOR Carcinogenesis
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):

1. Quantify the frequency and progression of preneoplastic foci (including both hyperplastic and dysplastic foci) in livers of C3H/HeNCrl mice irradiated with either 137Cs gamma-rays or HZE ions.

2. Examine irradiated liver for evidence of increased oxidative damage and alterations in the regulation of inflammatory processes.

3. Determine tumorigenic effects following HZE and gamma-ray irradiation in murine models of hepatocellular carcinoma in which secondary “promoting” events play a significant role.

Resources (None Listed)