Task Tissue-specific acute and late molecular surveillance of particle radiation effects (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Molecular Surveillance
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Examine the genetic damage to the genome by monitoring changes in transgene MF and cytogenetic changes in the peripheral blood and bone marrow lymphocytes as a function of fluence, dose protraction of either pure or mixed particle beams. Beam characteristics in space are critical variables in space and tissue-specific biological effects are important in determining relative risks in space explorations
  2. Measure the dose- and temporal- dependence of HZE radiation-induced alterations in gene expression and the transgene in liver tissue and compare the results with those previously measured in the brain and the spleen. Excess relative risk in liver cancer and non-cancer liver disease or cirrhosis has been demonstrated in Atomic bomb survivors and thorotrast patients
  3. Advance our understanding of the molecular basis for mutation by surveying the transcription activation of target genes in the brain tissue. We will focus our research on examining the expression of proinflammatory cytokines, eg. TNFalpha and interleukin-1, and the neuronal cell adhesion molecule NCAM-1. These genes have been shown to be induced in the mouse brain after low LET exposures.
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