Task Links Between Persistent DNA Damage, Genome Instability, and Aging (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Short Title: DNA Aging
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Department of Energy (DoE)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):

There is considerable overlap between cellular and molecular changes that occur in response to low doses of ionizing radiation and those that occur during aging. Both processes are characterized by accumulation of persistent DNA damage ("wear and tear" on the genome), accumulation of protein and lipid oxidation products, loss of regenerative capacity at the cellular and tissue level, and increased incidence of cancer. These observations support a hypothesis that exposure to low-dose ionizing radiation accelerates normal, aging-related tissue changes.

We have investigated this hypothesis using a genetically tractable model organism, the Japanese medaka fish. The medaka is a whole-animal vertebrate model that preserves some of the advantages of cell culture systems, including low cost, fast results, ease of gene activation and silencing, and accessibility to optical microscopy.

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