Task Low Dose IR Activation of TGF-Beta 1-IGF-1-sCLU In Vivo: Mechanisms, Functions of a Changing Microenvironment (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: TGF-Beta
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Department of Energy (DoE)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Directed
Aims:

This work focused on the mechanisms by which TGF-β1 can over-come p53 suppression and describes the discovery that Klotho, an agent important in aging, can suppress TGF-β1-induction of IGF-1-sCLU expression.

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