Task Mitochondrial-Derived Oxidants and Cellular Responses to Low Dose/Low LET Ionizing Radiation (Completed)
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Mitochondrial Oxidants
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Department of Energy (DoE)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Directed
Aims:
  1. Determine if cells with mutations in succinate dehydrogenase (SDH) subunits C and D (SDHC and SDHD in mitochondrial complex II) demonstrate increases in steady-state levels of reactive oxygen species (ROS; O2 and H2O2) as well as demonstrating increased sensitivity to low dose/low LET radiation (?10 cGy) in vitro.
  2. Determine if specific mitochondrially-derived ROS contributed to increases sensitivity to low dose/low LET radiation in cells containing mutations in SDH subunits in vitro.
  3. Determine if a causal relationship exists between persistent increases in mitochondrial ROS production, alterations in electron transport chain proteins, and genomic instability in the progeny of irradiated cells.
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