HRR - Task - Oxidative Stress and Skeletal Health with Low Dose, Low LET Ionizing Radiation

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- CV-102
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Oxidative Stress and Skeletal Health with Low Dose, Low LET Ionizing Radiation (Completed)

Last Published: 04/20/22 11:43:24 AM (Central)

Task Book: Entry Unavailable
Principal Investigator: Globus, Ruth

Short Title: Skeletal Health

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Department of Energy (DoE)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Directed

Aims:

Study how prior exposure to low dose radiation regulates oxidative metabolism within bone and contributes to bone loss caused either by subsequent high, challenge doses of radiation or by aging.

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Annual and Final Reports

Internal Customers:
None External Customers:
None

Mappings

Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Oxidative Stress and Skeletal Health with Low Dose, Low LET Ionizing Radiation

Related Tasks (119)

Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance, Exercise Capacity, and Risk of Cardiac Arrhythmias (ICV-Bungo/Levine)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Animal radiation study (Radiation Pilot-Westby, Completed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Bracelet Investigation (Brazlet Dulchavsky, Completed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Validation of On-Orbit Methodology for the Assessment of Cardiac Function and Changes in the Circulating Volume Using Ultrasound and Braslet-M Occlusion Cuffs, SDTO 17011 U/R (Braslet-M -- Duncan, Completed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones (Integrative CM-Levine, Completed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Identification of cardiometabolic vulnerabilities caused by effects of synergistic stressors that are commonly encountered during space missions (Cardiometabolic Vulnerabilities-Shea)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Determining the Effect of Space Flight on the Incidence of Cardiovascular Risk Factors and Disease (CV Data Mining-Barstow)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Lunar Analog Bed Rest Development (N/A, Closed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Temperature Regulatory and Cardiovascular Responses to Exercise During Long-Duration Spaceflight

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Space Radiation Risk Assessment Project-Cucinotta

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Early Markers of Space-Radiation Induced Human Cataractogenesis

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Effects of Estrogen on Cataract Induction After Exposure to High LET Radiation

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Human endothelial cells in 2-D and 3-D systems; non-cancer effects and space-related radiations

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Mechanisms, early events, and dose dependence of radiation-induced atherosclerosis

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Ionizing Radiation and its Effects on Cardiovascular Function in the Context of Space Flight

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

A Metabolomics and Mouse Models Approach to Study Inflammatory and Immune Responses to Radiation

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Non-Invasive Early Detection and Molecular Analysis of Low X-ray Dose Effects in the Lens

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Determination of the magnitude and time course of cardiovascular alterations during a simulated extended stay lunar mission

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Cardiovascular Imaging and Strategies to Mitigate the Risk for Cardiac Events in Astronauts During Prolonged Spaceflight (Cardiac Risk-Imaging -- Levine, Completed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Impact of Long Duration Space Flight On Cardiac Structure and Function (Long Duration-Cardiac -- Thomas)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Evaluation of Space Radiation-induced Myocardial and BM-derived EPC Damage and Assessment of Associated Long-term Degenerative Cardiovascular Risks

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Effects of Intestinal Microflora on High-LET Radiation Mediated Toxicity and Genomic Instability

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Defining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Lee)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Artificial Gravity Exposure Effects on Cardiovascularly Deconditioned Women's and Men's Orthostatic Intolerance Limit (Ames AG EPSCoR-Evans, Completed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Effects of high dietary heme iron and radiation on cardiovascular function (Radiation/Iron, CVD-Westby, Completed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Molecular mechanisms underlying heart failure and arrhythmias in astronauts (1-year NSBRI Postdoctoral Fellowship) (Molecular Arrhythmias-Gershovich/Werhans, Completed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Lunar analog pilot study (LAPS-Cromwell, Closed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Effect of Space Radiation on degenerative tissue disease, genetic Instability and Oxidative DNA Damage in Ataxia Telangiectasis Deficient Mice

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Precise Assessment of Prevalence and Progression of Lens Opacities in Astronauts as a Function of Radiation Exposure During Space Flight and Development of Improved Routine Clinical Assessment of Ocular Lens Status

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Mechanisms of Ocular Cataracts

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Low Dose Radiation Cataract

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Echocardiographic Assessment of Cardiovascular Adaptation and Countermeasures in Microgravity (Cardio Adaptation-Thomas, Completed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Proteomic Profiling of Human Heart Tissue Exposed to Microgravity (Proteomic Heart-Bowles, Completed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Microgravity Associated Compartmental Equilibration (Dulchavsky)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Fluid Distribution before, during and after Prolonged Space Flight (Hargens)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance (Stenger)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Targeting NO/IKK Signaling to Counteract Hemodynamic Flow-Dependent Endothelial Dysfunction and Vascular Damage after Space Radiation (Endothelial Dysfunction SR-Natarajan, Active)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Recovery of Functional Performance Following Long Duration Space Flight (Reschke)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Radiation Induced Cardiovascular Oxidative Stress: Thiol Modification of Proteins and Novel and Sensitive Biomarkers (Thiol Mod-Berkowitz, Completed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

The Development of a NASA/NSBRI Risk Calculator to Estimate the Short Term Risk of an Acute Coronary Event in Astronauts (CHARM-Khera, Completed)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

The Effects of Space Radiation on Stem Cells and Vascular and Cardiac Disease

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Radiation-Induced Early Changes in Gene and Protein Expression, Lipid Oxidative States, and Vascular Function Related to Atherosclerosis

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Influence of Exercise Modality on Cerebral-Ocular Hemodynamics and Pressures [EXERCISE MODALITY/SCOTT]

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Effects of short term hypercapnia during head-down tilt on ocular structures, cerebral blood flow, and visual acuity in healthy human subjects [CO2 TILT/LAURIE]

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Improving CV Risk Prediction -- Biomarkers and Beyond, Implications for Astronaut Selection and Monitoring During Prolonged Spaceflight (CV BIOMARKERS / DE LEMOS / ACTIVE)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Combined Effects of Space Radiation and Microgravity on the Function of Human Capillaries and the Endothelial Barrier: Implications for Degenerative Disorders

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Development of a Flow-Perfused and Immunocompetent 3-D Vascular Model for Radiation Risk Assessment of Cardiovascular Disease and Countermeasure Screening

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Determination of risk for and occurrence of heart disease from space radiation

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Long-Term Effect of Space Radiation on Cardiomyocyte Turnover

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Space Radiation Risk Assessment Project

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Integrated Cardiovascular (ICV) 2.0: Assessing the Risk for Atrial Fibrillation in Astronauts During Long Duration Spaceflight [INTEGRATED CARDIOVASCULAR 2/LEVINE]

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Biomarker Assessment for Identifying Heightened Risk for Cardiovascular Complications During Long-Duration Space Missions [IMAGING AND OMICS - CV RISK/LINDNER]

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Center for Research on Cardiac and Vascular Effects of Space Radiation

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Million Worker and Veteran Study

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Proteomic Signatures of Space Radiation Induced Cardiovascular Degeneration

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Identification of Functional Metabolomic Profiles Contributing to Physiological Adaptations to Simulated Spaceflight. (Rana)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Candidate nutritional countermeasure to mitigate adverse effects of spaceflight (Schreurs)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Gravitational dose and multi-system physiologic response

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Mitigating radiation-induced bone loss via dietary modulation of inflammatory cytokines (Bloomfield)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

VIIP Simulations of CSF, Hemodynamics and Ocular Risk (Ethier)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Effects of chronic and single-dose charged particle exposure on cardiac function and structure in multiple animal models

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Degenerative Cardiovascular Disease Risks Due to Single HZE or Mixed Ion Radiation

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Tissue Sharing Project-Effects of space radiation on the cardiac mitochondrial stress response

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Attenuation of Space Radiation-induced Pro-oxidant and Fibrotic Signaling in the Heart by Nutritional and Genetic Interventions: Adventures in Tissue Sharing

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Galactic Cosmic Ray Simulator and Mitigation Project

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

GCR Simulation Dose Rate Studies

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Multi-Model Ensemble Risk Assessment

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Space Relevant Radiation-Induced Cardiovascular Disease Risk Thresholds: Effect of Gender on the Outcome

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Sex- and Apo E-specific late CNS and cardiovascular effects of space radiation

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Imaging and Serum Biomarkers to Predict and Identify Early Cardiac Injury from Radiation Exposure

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Quantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

A determination of bioactive proteins secreted by the human vasculature in response to low dose space radiation

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Predictive Biomarkers for Space Radiation Induced Cancer and Cardiovascular Injury Risk Assessment

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Effects of low-dose radiation on neurovascular remodeling and blood-retina barrier function in mice, rats and rabbits (Mao)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Gamma-tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Telomeres and the One Year Mission Project

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Defining the relationship between simulated weightlessness and space radiation on cardiovascular disease, and the effectiveness of a countermeasure

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Countermeasures to Radiation Induced Cardiomyopathy

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Variation in CNS damage signaling and blood sentinels of neuropathology after exposure to space radiation.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Cardiovascular Disease Data Mining Phase II with Cooper Clinic

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Characterization of Jugular Venous Blood Flow during Acute Fluid Shifts (Marshall-Goebel)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Predicting acute cardiovascular and ocular changes due to changes in the gravitational vector and effects of countermeasures - Lab (Diaz Artiles)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Coronary Anatomy and Physiology During 1 Year in Space - ISS (Levine)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CVD Monitoring on Deep Space Gateway

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Rodent Lunar Stays

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CVD Integrated Flight Countermeasure Study on ISS

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CVD Integrated Flight Countermeasures Study for Deep Space Gateway and Lunar

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Development for Rodent Lunar Stays - Lab

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight (Taylor)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Venous Thromboembolism Characterization - ISS

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Determining the Dose Response Profile of the Headward Fluid Shift during Varying Gravity Levels (Lee)

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Maturation Task - CVD CM based on Weightlessness to SCLT/HMTA

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Maturation Task - CVD CM Combined Effects to SCLT/HMTA

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Maturation Task - CVD Standards based on Weightlessness to OCHMO

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

Effect of Space Radiation on Innate Immune System Homeostasis Drives Immune and Endothelial Cell Dysfunction and Neurodegeneration

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Space radiation exposure and risk mediated by clonal hematopoiesis.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Integration of In-Silico and In-Vivo Models for Determining Preclinical Indicators and/or Integrated Biomarkers of Radiation-Induced Vascular Dysfunction.

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Radiation resistance conferred by small proline rich repeat proteins (SPRRs).

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Risk Quantification Pilot with IMM for HSRB

Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

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Risk Approach Plans (2)

This task can be found in the following Risk Approach Plans.

Cancer Risk Approach plan
Cardiovascular Risk Approach plan

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