HRR - Task - Oxidative Stress and Skeletal Health with Low Dose, Low LET Ionizing Radiation

Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance, Exercise Capacity, and Risk of Cardiac Arrhythmias (ICV-Bungo/Levine, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Animal radiation study (Radiation Pilot-Westby, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Bracelet Investigation (Brazlet Dulchavsky, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Validation of On-Orbit Methodology for the Assessment of Cardiac Function and Changes in the Circulating Volume Using Ultrasound and Braslet-M Occlusion Cuffs, SDTO 17011 U/R (Braslet-M -- Duncan, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones (Integrative CM-Levine, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Identification of cardiometabolic vulnerabilities caused by effects of synergistic stressors that are commonly encountered during space missions (Cardiometabolic Vulnerabilities-Shea, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Gender Differences in Bedrest: Autonomic and Neuroendocrine Changes and Vascular Responses in Lower and Upper Extremities (Gender Differences-Platts, Completed)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effects of emotional stress on the cardiovascular system (Stress and CV Health-TBD, Planned)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Determining the Effect of Space Flight on the Incidence of Cardiovascular Risk Factors and Disease (CV Data Mining-Barstow, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Temperature Regulatory and Cardiovascular Responses to Exercise During Long-Duration Spaceflight

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Dose-Rate Effects and Components of Systems Governing Variations in Susceptibility for Carcinogenic and Acute Radiation Risks following Gamma-Ray, Proton, or HZE Irradiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Patterns of Energy Deposition by HZE Particles in Cellular Targets

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Integrated Radiation Analysis and Design Tools

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Space Radiation Risk Assessment Project-Cucinotta

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Early Markers of Space-Radiation Induced Human Cataractogenesis

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Effects of Estrogen on Cataract Induction After Exposure to High LET Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Human endothelial cells in 2-D and 3-D systems; non-cancer effects and space-related radiations

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Mechanisms, early events, and dose dependence of radiation-induced atherosclerosis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Ionizing Radiation and its Effects on Cardiovascular Function in the Context of Space Flight

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Measurements and Transport Phase 2 Physics Project

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Comparative Analysis of Charged Particle-Induced Autosomal Mutations in Murine Tissues and Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Role of high-LET radiation-induced mitotic catastrophe in mutagenesis: implication for carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms of the Repair of HZE Induced DNA Double-Strand Breaks in Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Telomeric proteins in the radiation/DNA damage response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

DNA Damage Clusters in Human Cell Transformation Induced by Single or Multiple Space Radiation Ion Exposures--Wilson

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

High energy proton dose-rate and mixed field effects on neoplastic transformation in vitro

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms for induction of bystander effects by high-energy particles in cells and tissues

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The Role of Gap-Junction Communication and Oxidative Metabolism in the Biological Effects of Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Structural Chromosome Aberrations Formed in Response to Changes in Proton Energy and Dose Rate

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Dose-rate effects of protons on the induction of genomic instability in vivo

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

miRNA profiling of radiation response: A systems biology approach to understanding regulation of proton and heavy ion dose effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

A Novel Biodosimetry Method

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The mechanism of excess relative risk on carcinogenesis induced by high-LET radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Dose rate effects on the mechanisms of space radiation induced delayed genomic instability

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Elucidating the Relationship Between the Effects of Various Radiation Qualities and Cancer Development Processes using Novel Flow-based Assays

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

HZE-induced mammary cancer development processes in murine and "humanized" models, and their influence on radiation quality functions

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

A mechanistic investigation of space radiation-induced carcinogenesis - NNX12AB88G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Radiation and Gliomagenesis: A Sensitive Model System to Evaluate the Tumorigenic Potential of HZE Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The Relation Between Mutagenesis and Genomic Instability After Particle Exposure In Vivo

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Radiation quality and the relationship between induced telomere dysfunction and mutagenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Epigenetic effects of radiation on epithelial cell self-renewal

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Impact of Radiation Quality on Cancer Processes in 2D and 3D Esophageal Cell Models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mitigating High Z Radiation Induced Genomic Instability by Non-Protein Thiols

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Solid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: The contribution of non-targeted effects in HZE cancer risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Lung Cancer Pathogenesis and HZE Particle Exposure

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Space Radiation and Intestinal Tumorigenesis: Risk Assessment and Counter Measure Development

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effects of prolonged exposure to space radiation on carcinogenesis and neuroendocrine differentiation in human prostate models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: NASA Specialized Center of Research on Radiation Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Integrated experimental and computational study of radiation induced matrix remodeling in a human skin equivalent

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Tissue-specific acute and late molecular surveillance of particle radiation effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Links Between Persistent DNA Damage, Genome Instability, and Aging

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Low Dose IR Activation of TGF-Beta 1-IGF-1-sCLU In Vivo: Mechanisms, Functions of a Changing Microenvironment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mitochondrial-Derived Oxidants and Cellular Responses to Low Dose/Low LET Ionizing Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

A Metabolomics and Mouse Models Approach to Study Inflammatory and Immune Responses to Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Systems Biology Model of Interactions Between Tissue Growth Factors and DNA Damage Pathways: Low Dose Response and Cross-Talk in TGFbeta and ATM Signaling

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Non-Invasive Early Detection and Molecular Analysis of Low X-ray Dose Effects in the Lens

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Systematic Identification of Genes and Signal Transduction Pathways Involved in Radio-Adaptive Response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Update of the Nuclear Fragmentation Cross Section Code NUCFRG2

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Quantum Multiple Scattering Model of Heavy Ion Fragmentation (QMSFRG)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Molecular Basis of DNA Repair and Protection from Apoptosis in Neuronal Progenitors Exposed to Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-101: Identify the combined effects of spaceflight stressors on identified surrogate cancer endpoints and shared biology with other degenerative diseases.

NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-101: Identify the combined effects of spaceflight stressors on identified surrogate cancer endpoints and shared biology with other degenerative diseases.

Cardiovascular Imaging and Strategies to Mitigate the Risk for Cardiac Events in Astronauts During Prolonged Spaceflight (Cardiac Risk-Imaging -- Levine, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Impact of Long Duration Space Flight On Cardiac Structure and Function (Long Duration-Cardiac -- Thomas, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Harderian Gland Tumorigenesis: Low-Dose-, Low-Dose-Rate-, and LET-Response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Evaluation of Space Radiation-induced Myocardial and BM-derived EPC Damage and Assessment of Associated Long-term Degenerative Cardiovascular Risks

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Mechanisms of Cell Survival Following Space Radiation-Induced Mitotic Catastrophe: Implications for Cancer Risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effects of Intestinal Microflora on High-LET Radiation Mediated Toxicity and Genomic Instability

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

A Novel Biological Countermeasure and Mitigator of High LET-Induced Cancer Progression

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

HZE-induced skin carcinoma: an in-vivo-like multicellular epithelial model system for analysis of radiation quality effects and DSB repair processes

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Duke NSCOR: Lung Cancer Risk From HZE Ions

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Risks Estimates and Mechanisms of Lung Cancer Pathogenesis After Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Mechanisms Underlying the Risk of HZE Particle-Induced Solid Tumor Development

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Impact of Individual Susceptibility and Previous Radiation Risk for Astronauts

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	Cancer-101: Identify the combined effects of spaceflight stressors on identified surrogate cancer endpoints and shared biology with other degenerative diseases.

Space Radiation Effects on Genomic and Epigenetic Stability: Influence of Radiation Quality and Genetic Predisposition-NNX13AK70G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Dependence of Radiation Quality on Charged Particle-induced Early and Late Damages in Chromosomes

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Defining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Cardio Ox-Platts, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Fast Neutron Dosimeter for the Space Environment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Evaluation of the effect of short duration spaceflight on hepatic nutrition, oxidative damage, and colon microflora

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

In vivo induction of chromosome instability and aberrant patterns of DNA methylation in hematopoietic stem/progenitor cells by heavy ions

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effects of high dietary heme iron and radiation on cardiovascular function (Radiation/Iron, CVD-Westby, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Characterization of the Tumor Spectrum Arising in HZE Ion Irradiated Outbred Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Synergistic Effects of Bcl2, Cigarette Smoking and Space Radiation on Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

High LET Radiation Induced Carcinogenesis: Epigenetic Mechanisms in Mouse Models of Human Cancers-NNX13AK69G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

3D Tissue Models for Study of Intercellular Signaling Stimulated by High Energy Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Targeting protein cross talk signaling as a biological predictor for space radiation cancer risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Molecular mechanisms underlying heart failure and arrhythmias in astronauts (1-year NSBRI Postdoctoral Fellowship) (Molecular Arrhythmias-Gershovich/Werhans, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Comparative Analysis of Charged Particle-Induced Autosomal Mutagenesis in Murine Tissue and Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Analysis of Clastogenic Factors in Gamma-Exposed Animals

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Molecular and cellular effects of heavy ion fragmentation due to shielding

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effect of Space Radiation on degenerative tissue disease, genetic Instability and Oxidative DNA Damage in Ataxia Telangiectasis Deficient Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

DNA Damage Responses Induced by HZE Particles In Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Precise Assessment of Prevalence and Progression of Lens Opacities in Astronauts as a Function of Radiation Exposure During Space Flight and Development of Improved Routine Clinical Assessment of Ocular Lens Status

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Mouse models approach for intestinal tumorigenesis estimates by space radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms of Ocular Cataracts

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Computational Modeling Of Chromosome Aberrations Produced By HZE Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Histone Acetyltransferases and the Cellular Response to DNA Damage

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

A role for homologous recombination in complex DSB repair after HZE particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Low Dose Radiation Cataract

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

T-helper Cell Gene Expression and Function in Response to Low Dose and Acute Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Radioprotectors and Tumors: Molecular Studies in Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Comparative Analysis of Fe-Induced Autosomal Mutations in Murine Tissue and Cell Lines

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Constructs

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms of Human Skin Responses to Low Radiation Doses and Dose Rates

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanistic and Quantitative Studies of Bystander Reponses in 3-D Human Tissues for Low-Dose Radiation Risk Estimation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The Contribution of Tissue Level Organization to Genomic Stability Following Low Dose/Low Dose Rate Gamma and Proton Irradiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Spectroscopic Dosimeter

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanism of Radiation-Induced Alteration of Astrocyte-Neuronal Coupling

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR Radiation Leukemogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Echocardiographic Assessment of Cardiovascular Adaptation and Countermeasures in Microgravity (Cardio Adaptation-Thomas, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Functional Role Of The Betaig-H3 Gene In High-Energy Heavy Ions-Induced Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Chromatid Painting for Chromosomal Inversion Detection

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

HZE Radiation: Modulation Of Genetic Effects By RNA Interference Of NHEJ

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Mechanisms of HZE Damage and Repair in Human Epithelial Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Methods for Real Time Measurement of Dose and Charged Particle Spectrum

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effect of Deep Space Radiation on Human Hematopoietic Stem and Progenitor Cell Function

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Early Detection of Inflammatory Response and the Subsequent Health Outcomes Due to High LET Particle Radiation: An Integrated Metabolomics Study

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Fundamental Biological studies of protein phosphorylation profiles after HZE exposure

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Risk Assessment of Space Radiation-Enhanced Colon Tumorigenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Risk Assessment of Space Radiation-Enhanced Colon Tumorigenesis--NNX08BA54G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Cytogenetic Study Of Heavy Ion-Induced Chromosomal Damage In Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Proteomic Profiling of Human Heart Tissue Exposed to Microgravity (Proteomic Heart-Bowles, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Microgravity Associated Compartmental Equilibration (MACE) [FLUID SHIFTS / DULCHAVSKY / ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Fluid Distribution before, during and after Prolonged Space Flight-NNX13AJ12G [FLUID SHIFTS / HARGENS / ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

NEXGEN Approaches to Chromatid Painting

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance [FLUID SHIFTS / STENGER / ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Targeting NO/IKK Signaling to Counteract Hemodynamic Flow-Dependent Endothelial Dysfunction and Vascular Damage after Space Radiation (Endothelial Dysfunction SR-Natarajan, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Recovery of Functional Performance Following Long Duration Space Flight (Reschke)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Mechanisms of the Repair of HZE Induced DNA Double-Strand Breaks in Human Cells - NNX12AH07G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo - CCSB

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure

Impact of Age, Genetics Variants and High LET Track Structure on Mammary Cancer Risk Estimates

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

High-LET Radiation, Reproductive Hormones and Chronic Inflammation: An Integrated Approach to Carcinogenesis Risk Estimate

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

A Systems Analysis of Progression-Phase Determinants of Radiation-Induced Carcinogenesis and its Modulation by Stem Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The Role of the Bone Marrow Microenvironment in Space Radiation-Induced Leukemogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

HZE Radiation Effects on Malignant Progression in Human Epithelial Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanistic Study of the Risk of Low Doses of HZE Particles on Human Cell Pre-Malignant Transformation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanism of Clustered DNA Double-strand Break Repair in Response to HZE Particles in Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mouse Glioma Models to Estimate Cancer Risks from HZE Particle Exposure

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms of low dose HZE alteration of neuronal-astrocytic coupling: The role of purinergic receptors and calcium signaling

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Radiation Induced Cardiovascular Oxidative Stress: Thiol Modification of Proteins and Novel and Sensitive Biomarkers (Thiol Mod-Berkowitz, Completed)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	Cancer-101: Identify the combined effects of spaceflight stressors on identified surrogate cancer endpoints and shared biology with other degenerative diseases.
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

The Development of a NASA/NSBRI Risk Calculator to Estimate the Short Term Risk of an Acute Coronary Event in Astronauts (CHARM-Khera, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

The Effects of Space Radiation on Stem Cells and Vascular and Cardiac Disease

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Solid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects-NNX11AK26G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Radiation-Induced Early Changes in Gene and Protein Expression, Lipid Oxidative States, and Vascular Function Related to Atherosclerosis

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

The Role of Oxidative Stress and Inflammation on Synaptic Functions After Exposure to Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	Cancer-101: Identify the combined effects of spaceflight stressors on identified surrogate cancer endpoints and shared biology with other degenerative diseases.
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Charged Particle Effects on the Ovary

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Defining the role of miR-182 in HZE-Induced Tumorigenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The Effect of High LET Radiation on Differentiation and Tumorigenesis in the Human Hematopoietic System: Modeling in vitro and in vivo for Risk Assessment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Contribution of GCR Exposure to Hematopoietic Stem Cell Dysfunction and Oncogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The Relation Between Mutagenesis and Genomic Instability After Particle Exposure In Vivo-NNX14AC97G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The Contribution of Delta Rays to the Chromosome Aberration Dose Response in Human Cells Irradiated with HZE Particles of Different Energy but the Same LET

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Influence of Exercise Modality on Cerebral-Ocular Hemodynamics and Pressures [EXERCISE MODALITY/SCOTT/ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effects of short term hypercapnia during head-down tilt on ocular structures, cerebral blood flow, and visual acuity in healthy human subjects [CO2 TILT/LAURIE/ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Improving CV Risk Prediction -- Biomarkers and Beyond, Implications for Astronaut Selection and Monitoring During Prolonged Spaceflight (CV BIOMARKERS / DE LEMOS / ACTIVE)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Deep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-101: Identify the combined effects of spaceflight stressors on identified surrogate cancer endpoints and shared biology with other degenerative diseases.

Combined Effects of Space Radiation and Microgravity on the Function of Human Capillaries and the Endothelial Barrier: Implications for Degenerative Disorders

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Development of a Flow-Perfused and Immunocompetent 3-D Vascular Model for Radiation Risk Assessment of Cardiovascular Disease and Countermeasure Screening

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Oxidative Stress and the Cancer Risk of Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-101: Identify the combined effects of spaceflight stressors on identified surrogate cancer endpoints and shared biology with other degenerative diseases.

Determination of risk for and occurrence of heart disease from space radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Molecular characterization of transmissible chromosome aberrations produced by ions of intermediate and high atomic number

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Exosomes and secretory factors as mediators of non-targeted effects of HZE particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Induction of Hepatocellular Carcinoma by Space Radiation: A Systems Biology Study of Causative Mechanisms

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Long-Term Effect of Space Radiation on Cardiomyocyte Turnover

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Radiation-induced apoptosis avoidance and colon tumorigenesis: Epigenetic regulation in adult stem cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Space Radiation Risk Assessment Project

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Mechanisms Underlying Charged Particle-Induced Disruption of CNS Function

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Space Radiation and Gastrointestinal Cancer: A Comprehensive Strategy for Risk Assessment and Model Development

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NASA Specialized Center of Research on Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

2022 NSCOR: CVD/Late CNS clinical MCM Assessment

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

2026 NSCOR: CVD/Late CNS MCM Assessment: Combined Spaceflight Stressors

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	Cancer-101: Identify the combined effects of spaceflight stressors on identified surrogate cancer endpoints and shared biology with other degenerative diseases.
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Integrated Cardiovascular (ICV) 2.0: Assessing the Risk for Atrial Fibrillation in Astronauts During Long Duration Spaceflight [INTEGRATED CARDIOVASCULAR 2/LEVINE/ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Biomarker Assessment for Identifying Heightened Risk for Cardiovascular Complications During Long-Duration Space Missions [IMAGING AND OMICS - CV RISK/LINDNER/ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Center for Research on Cardiac and Vascular Effects of Space Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Million Worker and Veteran Study

Common Item(s)
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Simulation of GCR-Induced Harderian Gland and Lung Tumorigenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Blood-based multi-scale model for cancer risk from GCR in genetically diverse populations

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

GCR Simulator Validation Studies with Human and Mouse Models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Individual Differences in the Neuronal and Behavioral Response to Exposure to HZE Particles

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Mechanistic Analysis of Particle Radiation-Induced Carcinogenesis Using Validated Mouse Glioma Models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mouse Models of Cancer Risk and Prevention from Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Proteomic Signatures of Space Radiation Induced Cardiovascular Degeneration

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Mars 600/900 Simulation I: Large Animal Chronic Studies

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

DNA damage in the ISS astronaut's lymphocytes and their association with stress-induced immune dysfunction (Honglu Wu) Functional immune

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Identification of Functional Metabolomic Profiles Contributing to Physiological Adaptations to Simulated Spaceflight. (Rana)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Candidate nutritional countermeasure to mitigate adverse effects of spaceflight (Schreurs)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

An Integrated Framework for Characterization of the Noncoding Genome and Epigenome in Astronauts (Mason)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Gravitational dose and multi-system physiologic response

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Center for Medical Countermeasures II – Cross Risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Center for Medical Countermeasures I - Cancer

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

2022 NSCOR-CVD/Late CNS: Impact of Combined Spaceflight Stressors

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	Cancer-101: Identify the combined effects of spaceflight stressors on identified surrogate cancer endpoints and shared biology with other degenerative diseases.
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Mars 600/900 Simulation II: Large Animal Chronic Studies

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Mitigating radiation-induced bone loss via dietary modulation of inflammatory cytokines (Bloomfield)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Computational Model Prediction & Biological Validation using Simplified Mixed Field Exposures for the Development of a GCR Reference

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Physical and Biological Modulators of Space Radiation Carcinogenesis: Mechanistically - Based Model Development for Space Radiation Risk Assessment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Biophysics Phase 1

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

VIIP Simulations of CSF, Hemodynamics and Ocular Risk (OPHTHALMIC MODELING CHANGES 2)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effects of chronic and single-dose charged particle exposure on cardiac function and structure in multiple animal models

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Degenerative Cardiovascular Disease Risks Due to Single HZE or Mixed Ion Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Tissue Sharing Project-Effects of space radiation on the cardiac mitochondrial stress response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Attenuation of Space Radiation-induced Pro-oxidant and Fibrotic Signaling in the Heart by Nutritional and Genetic Interventions: Adventures in Tissue Sharing

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Galactic Cosmic Ray Simulator and Mitigation Project

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

GCR Simulation Dose Rate Studies

Common Item(s)
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Contracted Study CM Validation I (Cancer)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Multi-Model Ensemble Risk Assessment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Inter-Agency Medical Countermeasures Studies

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease

Contracted Study CM Validation II (Cross Risk)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Evaluation of Sex-Specific Differences in Lung Cancer Radiation Risks and Recommendations for Use in Transfer Models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Multi-model Ensemble Risk Assessment Maturation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Protracted exposure to NASA's GCR-Simulator: Cytogenetic validation and beam time optimization

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Space Relevant Radiation-Induced Cardiovascular Disease Risk Thresholds: Effect of Gender on the Outcome

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: To determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.