Task Non-Invasive Early Detection and Molecular Analysis of Low X-ray Dose Effects in the Lens (Completed)
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: Low Dose Lens
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Department of Energy (DoE)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Directed
Aims:

The focus of this project is to evaluate radiation cataract dose response and mechanisms associated with low-linear energy transfer (LET) X-rays. We aim to investigate the natural history of Rayleigh light scattering changes in pre-cataractous lenses of mice exposed to radiations using a fully-validated, performance-tested quasi-elastic light scattering (QLS) instrument developed by Dr. Goldstein and colleagues at Boston University. 

The goal of the project is to test the hypothesis that exposure to low dose ionizing radiation induces dose- and time-dependent changes in the molecular organization of the lens that can be quantitatively detected and tracked by infrared quasi-elastic light scattering (OLS) technology

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