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Task Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Task Book: Entry
Principal Investigator: Britten, Richard
Short Title: HZE Cognitive
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

1) identify the high-LET radiations that have the greatest impact on the ability of animals to recall imprinted memories and to learn new memory skills;

2) use PET imaging to identify the regions of the brain that are functionally inactivated when brain function is inhibited by Hze radiation

3) establish the relative importance of radiation-induced cell death and signal malfunction in the inhibition of brain function after exposure to radiations with low, medium and high-LETs;

4) develop a blood-based assay that can be used to monitor the astronauts for early signs of radiation-induced memory function deficit.

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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskProteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
You are here!TaskProteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers
RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskProteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers
RiskRisk of Radiation Carcinogenesis
You are here!TaskProteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers