Task Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: HZE Cognitive
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

1) identify the high-LET radiations that have the greatest impact on the ability of animals to recall imprinted memories and to learn new memory skills;

2) use PET imaging to identify the regions of the brain that are functionally inactivated when brain function is inhibited by Hze radiation

3) establish the relative importance of radiation-induced cell death and signal malfunction in the inhibition of brain function after exposure to radiations with low, medium and high-LETs;

4) develop a blood-based assay that can be used to monitor the astronauts for early signs of radiation-induced memory function deficit.

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