Short Title:
DNA Repair
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
In the present proposal, we introduce an in vitro model of neural progenitors (neurospheres), which is derive from the brain of mouse embryo from neurodegenerative transgenic mice to study the detrimental effects of space radiation at the mechanistic level. Using this biological model, we will study DNA damage repair and apoptosis of proliferating and differentiated neural progenitor exposed to low dose of high charge and energy nuclei and protons.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Study will provide evidence on impact of space radiation on DNA repair and apoptotic processes in a neural progenitor cell model, and will provide mechanistic insights in support of CNS gap 2 closure.
Internal Customers:
None
External Customers:
None