HRR - Task - Molecular Basis of DNA Repair and Protection from Apoptosis in Neuronal Progenitors Exposed to Space Radiation

Gender Differences in Bedrest: Autonomic and Neuroendocrine Changes and Vascular Responses in Lower and Upper Extremities (Gender Differences-Platts, Completed)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Dose-Rate Effects and Components of Systems Governing Variations in Susceptibility for Carcinogenic and Acute Radiation Risks following Gamma-Ray, Proton, or HZE Irradiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Patterns of Energy Deposition by HZE Particles in Cellular Targets

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.

Integrated Radiation Analysis and Design Tools

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Space Radiation Risk Assessment Project-Cucinotta

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.

Effects of Estrogen on Cataract Induction After Exposure to High LET Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mechanisms, early events, and dose dependence of radiation-induced atherosclerosis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Measurements and Transport Phase 2 Physics Project

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Comparative Analysis of Charged Particle-Induced Autosomal Mutations in Murine Tissues and Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Role of high-LET radiation-induced mitotic catastrophe in mutagenesis: implication for carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mechanisms of the Repair of HZE Induced DNA Double-Strand Breaks in Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Telomeric proteins in the radiation/DNA damage response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

DNA Damage Clusters in Human Cell Transformation Induced by Single or Multiple Space Radiation Ion Exposures--Wilson

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

High energy proton dose-rate and mixed field effects on neoplastic transformation in vitro

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms for induction of bystander effects by high-energy particles in cells and tissues

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The Role of Gap-Junction Communication and Oxidative Metabolism in the Biological Effects of Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Structural Chromosome Aberrations Formed in Response to Changes in Proton Energy and Dose Rate

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Dose-rate effects of protons on the induction of genomic instability in vivo

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

miRNA profiling of radiation response: A systems biology approach to understanding regulation of proton and heavy ion dose effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

A Novel Biodosimetry Method

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

The mechanism of excess relative risk on carcinogenesis induced by high-LET radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Dose rate effects on the mechanisms of space radiation induced delayed genomic instability

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Elucidating the Relationship Between the Effects of Various Radiation Qualities and Cancer Development Processes using Novel Flow-based Assays

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

HZE-induced mammary cancer development processes in murine and "humanized" models, and their influence on radiation quality functions

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

A mechanistic investigation of space radiation-induced carcinogenesis - NNX12AB88G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Radiation and Gliomagenesis: A Sensitive Model System to Evaluate the Tumorigenic Potential of HZE Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

The Relation Between Mutagenesis and Genomic Instability After Particle Exposure In Vivo

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Radiation quality and the relationship between induced telomere dysfunction and mutagenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Epigenetic effects of radiation on epithelial cell self-renewal

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Sensory Stimulation Augmentation Tools (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Psychomotor Vigilance Test (PVT) on ISS

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Promoting behavioral health, cognitive, sensorimotor and immune function using guided imagery to augment exercise training in an isolated and confined spaceflight analog environment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Objective Detection, Evaluation and Countermeasures for In-flight Depression

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Optical Computer Recognition of Stress, Affect and Fatigue During Performance in Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Objective Monitoring of Crew Neurobehavioral Functions (105-day Russian Chamber Study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Neurobehavioral Conditions List for Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Asthenia Literature Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Voice Content Analysis Techwatch

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Detection & Prevention of Neurobehavioral Vulnerability to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Evidence Review: Cognition in Long Duration Missions in Isolated, Confined and Extreme Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Validation of Assessment Tests and Countermeasures for Detecting and Mitigating Changes in Cognitive Function During Robotics Operations

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Integrated Cognitive Assessment: Combining Measurement, System, and Mission

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Neurostructural, Cognitive, and Physiologic Changes During a 1-year Antarctic Winter-Over Mission

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The Prediction of the Onset of Anxiety Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

White Paper on the Onset of Depression

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Meta-Analysis of the effects of ICE environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Evidence Review on Identification of Psychosocial Characteristics in ICE Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Growth and Resilience for Long Duration Exploration Missions(RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effects of Well-Being on Performance in ICE Environments (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individual differences and adaptation to Isolated, Confined, and Extreme (ICE) environments (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Self-Guided Depression Treatment on Long-Duration Spaceflights

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

A Multi-Media, Computer-Based, Self-Directed, Autonomous, Stress and Anxiety-Management Countermeasure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Behavioral Issues Associated with Long Duration Space Missions: Review of Astronaut Journals

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Asynchronous Behavioral Health Treatment Techniques

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Immune Function Data Mining

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Sleep-Wake Actigraphy and Light Exposure During Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Environmental Factors Evidence Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The Biological Basis of Emotional Support for Long Duration Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Determine best methods to maintain contact with astronaut social support network during pre-mission training (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Evidence Review on Biomarkers of Individual Vulnerabilities to Sleep Loss and Circadian Desynchronization

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

AD ASTRA: Automated Detection of Attitudes and States through Transaction Recordings Analysis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Team Risk Standardized Measures Workshop

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Operational Evaluation of Photic Countermeasure to Improve Alertness, Performance, and Mood during Nightshift Work on a 105-Day Study (105-day Russian Chamber Study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Countermeasure for Managing Interpersonal Conflicts in Space: A Continuation Study

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

ANSIBLE: A Network of Social Interactions for Bilateral Life Enhancement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Dynamic Team Role Allocation in Long Duration, Exploration Missions: Identification of Roles, Triggers, and Measurement Tools

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optimizing Light for Long Duration Space Exploration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Blue Light for Enhancing Alertness in Space Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Feasibility Pilot Study on Acute Biological and Behavioral Responses to the Solid State Lighting Modules for the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Testing solid state lighting countermeasures to improve circadian adaptation, sleep, and performance during high fidelity analog and flight studies for the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Develop and Implement Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects (pilot study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Designing Individual Countermeasures to Reduce Sleep Disruption and Improve Performance and Alertness in Space

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Countermeasures for Performance Deficits from Sleep Loss and Workload in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Individualized Fatigue Meter for Space Exploration (SBIR Phase II)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Survey of On-Orbit Sleep Quality (Sleep Quality Questionnaire)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Phoenix Scout Lander: Countermeasures Testbed for Spaceflight Ground Controllers

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

A Comprehensive Fatigue Management Program and an Evaluation of a Photic Countermeasure for Mission Controllers

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Impact of Radiation Quality on Cancer Processes in 2D and 3D Esophageal Cell Models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mitigating High Z Radiation Induced Genomic Instability by Non-Protein Thiols

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Solid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

NSCOR: The contribution of non-targeted effects in HZE cancer risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

NSCOR: Lung Cancer Pathogenesis and HZE Particle Exposure

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

NSCOR: Space Radiation and Intestinal Tumorigenesis: Risk Assessment and Counter Measure Development

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Effects of prolonged exposure to space radiation on carcinogenesis and neuroendocrine differentiation in human prostate models

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: NASA Specialized Center of Research on Radiation Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Integrated experimental and computational study of radiation induced matrix remodeling in a human skin equivalent

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Tissue-specific acute and late molecular surveillance of particle radiation effects

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Links Between Persistent DNA Damage, Genome Instability, and Aging

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Low Dose IR Activation of TGF-Beta 1-IGF-1-sCLU In Vivo: Mechanisms, Functions of a Changing Microenvironment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mitochondrial-Derived Oxidants and Cellular Responses to Low Dose/Low LET Ionizing Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Neurodegeneration and Adaptation in Response to Low-Dose Photon Irradiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Systems Biology Model of Interactions Between Tissue Growth Factors and DNA Damage Pathways: Low Dose Response and Cross-Talk in TGFbeta and ATM Signaling

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Oxidative Stress and Skeletal Health with Low Dose, Low LET Ionizing Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Systematic Identification of Genes and Signal Transduction Pathways Involved in Radio-Adaptive Response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Update of the Nuclear Fragmentation Cross Section Code NUCFRG2

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Quantum Multiple Scattering Model of Heavy Ion Fragmentation (QMSFRG)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

The Impact of HZE Particles on Adult Neural Stem Cells and Neurogenesis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Epigenetic Control of Radiogenic Damage Processing in C. elegans

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Use of a molecular marker of learning and memory to assess effects of 56Fe irradiation on hippocampus-dependent cognition and neurogenesis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Cognitive/Behavioral, Sensory, & Motor Changes Induced by Solar Particle Event (SPE) and Galactic Cosmic Ray (GCR) Irradiations

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Development and use of human 3-Dimensional tissue culture models for the study of space radiation effects on the central nervous system

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Virtual Reality (VR) Technologies for Enhancing Behavioral Health

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Assessing Team Performance in Autonomous Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Harderian Gland Tumorigenesis: Low-Dose-, Low-Dose-Rate-, and LET-Response

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mechanisms of Cell Survival Following Space Radiation-Induced Mitotic Catastrophe: Implications for Cancer Risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Effects of Intestinal Microflora on High-LET Radiation Mediated Toxicity and Genomic Instability

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

A Novel Biological Countermeasure and Mitigator of High LET-Induced Cancer Progression

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

HZE-induced skin carcinoma: an in-vivo-like multicellular epithelial model system for analysis of radiation quality effects and DSB repair processes

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Duke NSCOR: Lung Cancer Risk From HZE Ions

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

NSCOR: Risks Estimates and Mechanisms of Lung Cancer Pathogenesis After Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

NSCOR: Mechanisms Underlying the Risk of HZE Particle-Induced Solid Tumor Development

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Impact of Individual Susceptibility and Previous Radiation Risk for Astronauts

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effects of Alphalipoic Acid on Irradiation Induced Cognitive Deficits (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Individualized Real-Time Neurocognitive Assessment Toolkit for Space Flight Fatigue

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Composing and Developing Resilient, Adaptive, and Self-Sustaining Teams for Long Duration Space Exploration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Two-Hit Model of Alzheimer's Disease

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Functional decline in mice with Alzheimer's-type neurodegeneration is accelerated by charge-particle radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Molecular Characterization of Long-term Degenerative CNS Risks from Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Space Radiation Effects on Genomic and Epigenetic Stability: Influence of Radiation Quality and Genetic Predisposition-NNX13AK70G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Dependence of Radiation Quality on Charged Particle-induced Early and Late Damages in Chromosomes

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Multi-Modal Neurodiagnostic Tool for Stress Monitoring

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Sleep Workshop

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Development and testing of biomarkers to determine individual astronauts' vulnerabilities to behavioral health disruptions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Individualized Behavioral Health Monitoring Tool

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Objective Monitoring of Crew Neurobehavioral Functions in Mars 520-Day Simulation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

CogGauge Enhancement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

South Pole Station: An Analogue for Human Performance During Long Duration Missions to Isolated and Confined Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optical Computer Recognition of Stress, Affect and Fatigue in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Self-Guided Multimedia Stress Management and Resilience Training

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Autonomous Behavioral Health Countermeasures for Spaceflight - Virtual Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Characterize Workload on the International Space Station (ISS) (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Fast Neutron Dosimeter for the Space Environment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Evaluation of the effect of short duration spaceflight on hepatic nutrition, oxidative damage, and colon microflora

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

In vivo induction of chromosome instability and aberrant patterns of DNA methylation in hematopoietic stem/progenitor cells by heavy ions

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Characterization of the Tumor Spectrum Arising in HZE Ion Irradiated Outbred Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Synergistic Effects of Bcl2, Cigarette Smoking and Space Radiation on Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Effects of Space Radiation on Hippocampal-Dependent Learning and Neuropathology in Wild-Type and Alzheimer's Disease Transgenic Mice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

High LET Radiation Induced Carcinogenesis: Epigenetic Mechanisms in Mouse Models of Human Cancers-NNX13AK69G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Effects of Space Radiation on the Function of Human Brain Capillaries and the Blood-brain-barrier: Implications for Neurodegenerative Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Molecular and Cellular Mechanisms of Space Radiation-Induced Changes in Hippocampal-Dependent Behavior

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

3D Tissue Models for Study of Intercellular Signaling Stimulated by High Energy Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Targeting protein cross talk signaling as a biological predictor for space radiation cancer risk

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Android App Incorporating the PVT to deliver individualized Fatigue Risk Management in Commercial Trucking

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Comparative Analysis of Charged Particle-Induced Autosomal Mutagenesis in Murine Tissue and Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Impact of Space Radiation Induced Neuroinflammation on Alzheimer and Parkinson Disease Pathology

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Analysis of Clastogenic Factors in Gamma-Exposed Animals

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Molecular and cellular effects of heavy ion fragmentation due to shielding

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effect of Space Radiation on degenerative tissue disease, genetic Instability and Oxidative DNA Damage in Ataxia Telangiectasis Deficient Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

DNA Damage Responses Induced by HZE Particles In Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Inflammation in the brain after particulate irradiation predisposes the hippocampus to a heightened vulnerability after a secondary insult

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Mouse models approach for intestinal tumorigenesis estimates by space radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Computational Modeling Of Chromosome Aberrations Produced By HZE Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

NSCOR: Progressive Alterations of Central Nervous System Structure and Function Are Caused by Charged Particle Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Histone Acetyltransferases and the Cellular Response to DNA Damage

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

A role for homologous recombination in complex DSB repair after HZE particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Speech monitoring of cognitive deficits and stress

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Low Dose Ionizing Radiation and HZE Particle Effects on Adult Hippocampal Neurogenesis: A Sensitive Indicator of CNS Microenvironmental Changes

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

T-helper Cell Gene Expression and Function in Response to Low Dose and Acute Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Radioprotectors and Tumors: Molecular Studies in Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Comparative Analysis of Fe-Induced Autosomal Mutations in Murine Tissue and Cell Lines

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Constructs

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Mechanisms of Human Skin Responses to Low Radiation Doses and Dose Rates

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Mechanistic and Quantitative Studies of Bystander Reponses in 3-D Human Tissues for Low-Dose Radiation Risk Estimation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

The Contribution of Tissue Level Organization to Genomic Stability Following Low Dose/Low Dose Rate Gamma and Proton Irradiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Spectroscopic Dosimeter

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Dose-rate and mixed field effects of protons and HZE nuclei on oxidative injury and stem cell plasticity in the CNS

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Replacement Lighting for Research and Training

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mechanism of Radiation-Induced Alteration of Astrocyte-Neuronal Coupling

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

NSCOR Radiation Leukemogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Neurochemical and Behavioral Effects of Exposure to Heavy Particles -- NNJ06HD93G

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Mathematical Modeling of Circadian/Performance Countermeasures

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

A Model of Circadian Disruption in the Space Environment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optical Computer Recognition of Performance Under Stress

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Development of a User Interface for the PVT SelfTest (PST)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Functional Role Of The Betaig-H3 Gene In High-Energy Heavy Ions-Induced Carcinogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Impact of HZE Particles Exposure on Proliferation and Differentiation of Human Neural System Cells

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Chromatid Painting for Chromosomal Inversion Detection

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

HZE Radiation: Modulation Of Genetic Effects By RNA Interference Of NHEJ

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

NSCOR: Mechanisms of HZE Damage and Repair in Human Epithelial Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Methods for Real Time Measurement of Dose and Charged Particle Spectrum

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Effect of Deep Space Radiation on Human Hematopoietic Stem and Progenitor Cell Function

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Early Detection of Inflammatory Response and the Subsequent Health Outcomes Due to High LET Particle Radiation: An Integrated Metabolomics Study

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

HZE Radiation Effects On Neuroinflammation: Role Of Cox-2

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Fundamental Biological studies of protein phosphorylation profiles after HZE exposure

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Risk Assessment of Space Radiation-Enhanced Colon Tumorigenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Risk Assessment of Space Radiation-Enhanced Colon Tumorigenesis--NNX08BA54G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Cytogenetic Study Of Heavy Ion-Induced Chromosomal Damage In Human Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Assessing the Impact of Communication Delay on Performance: An Examination of Autonomous Operations Utilizing the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Selection Studies Retrospective

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Net Habitable Volume Community of Practice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

NEXGEN Approaches to Chromatid Painting

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

Ultra-Short Light Pulses as Efficient Countermeasures for Circadian Misalignment and Objective Performance and Subjective Alertness Decrements

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The ISS Dynamic Lighting Schedule: An in-flight lighting countermeasure to facilitate circadian adaptation, improve sleep and enhance alertness and performance on the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Markers of Susceptibility to Neurobehavioral Decrements in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Detection and Prevention of Neurobehavioral Vulnerability to Space Radiation II

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mechanisms of the Repair of HZE Induced DNA Double-Strand Breaks in Human Cells - NNX12AH07G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo - CCSB

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Impact of Age, Genetics Variants and High LET Track Structure on Mammary Cancer Risk Estimates

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Charged Particle Effects on Neuronal Injury, Plasticity and Neurodegeneration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

High-LET Radiation, Reproductive Hormones and Chronic Inflammation: An Integrated Approach to Carcinogenesis Risk Estimate

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-301: Determine the tissue-specific contributions to overall space radiation carcinogenic risk and whether there are sex-specific dependencies.
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

A Systems Analysis of Progression-Phase Determinants of Radiation-Induced Carcinogenesis and its Modulation by Stem Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis
	Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases.

Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons and HZE Particles

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

The Role of the Bone Marrow Microenvironment in Space Radiation-Induced Leukemogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
	Risk of Radiation Carcinogenesis