Short Title:
Systemic Inflammation
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
|
|
Aims:
we will explore the effects of protons and mixed particle radiation, at doses and fluences expected during space travel, in the brain and lung as well as the systemic circulation of mice. Dose and time dependent alteration in inflammatory indices will be correlated with brain and lung degenerative changes, including failure of hippocampal neurogenesis and alterations in hippocampal dependent learning. We will also explore whether space radiation influences Alzheimer's disease pathogenesis using a unique transgenic mouse model and lung inflammation following challenge with inhaled lipopolysaccharide.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual Report
Internal Customers:
Space Radiation
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual Report
Internal Customers:
Space Radiation
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Annual Report
Internal Customers:
Space Radiation
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Final Report
Internal Customers:
Space Radiation
External Customers:
None