Short Title:
Oxidative Stress
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
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Aims:
The project will characterize behavioral, electrophysiological, biochemical and structural changes both in vivo and in vitro. Radiation-elicited oxidative stress mechanisms will be investigated as important mediators of the biological responses in both wild type and mutant animals. In addition to characterization of normal tissue responses, the potential enhancement of three late risks by radiation exposure will be explored. These are seizures, ischemic injury and traumatic injury. Mathematical models of the neurotoxicity responses will developed for use in estimating risks and fitted to project-specific data and previously-published observations.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Evidence on the roles of reactive oxygen species and neurogenesis in mediating the effects of radiation exposure on acute and late CNS function. Evidence will contribute to CNS gap 1 closure by providing mechanistic insight into acute/early radiation effects on the CNS.
Internal Customers:
Space Radiation
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Evidence on the roles of reactive oxygen species and neurogenesis in mediating the effects of radiation exposure on acute and late CNS function. Evidence will contribute to CNS gap 1 closure by providing mechanistic insight into acute/early radiation effects on the CNS.
Internal Customers:
None
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Evidence on the roles of reactive oxygen species and neurogenesis in mediating the effects of radiation exposure on acute and late CNS function. Evidence will contribute to CNS gap 1 closure by providing mechanistic insight into acute/early radiation effects on the CNS.
Internal Customers:
None
External Customers:
None