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Task NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System (Completed)
Last Published:  04/20/22 11:43:24 AM (Central)
Task Book: Entry
Principal Investigator: Nelson, Gregory
Short Title: Oxidative Stress
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
The project will characterize behavioral, electrophysiological, biochemical and structural changes both in vivo and in vitro. Radiation-elicited oxidative stress mechanisms will be investigated as important mediators of the biological responses in both wild type and mutant animals. In addition to characterization of normal tissue responses, the potential enhancement of three late risks by radiation exposure will be explored. These are seizures, ischemic injury and traumatic injury. Mathematical models of the neurotoxicity responses will developed for use in estimating risks and fitted to project-specific data and previously-published observations.
Resources (None Listed)
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RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?
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