HRR - Task - High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo

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High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo (Completed)

Last Published: 07/30/20 02:45:15 PM (Central)

Task Book: Entry
Principal Investigator: Naidu, Mamta

Short Title: OPC

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:
Our project will determine the effects of high LET radiation on the nuclear and mitochondrial BER in two systems; the central glia-4 (CG-4), a glial progenitor cell line that can differentiate into OL or astrocytes, and in OPC cells isolated from rat spinal cord.

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Research will determine the effects of high LET radiation on the nuclear and mitochondrial DNA repair pathways in cells of the CNS. This data will provide evidence for risk characterization in support of CNS Gap 2 closure.

Internal Customers:
None External Customers:
None

Mappings

Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo

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PRRs (2)

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Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?